Epiphanios 50 was a patrikios. During the questioning of Maximos 10 (Maximus the Confessor) at Constantinople in 652/653 Troilos 3 accused Maximos 10 of mocking the assembly; the patrikios Epiphanios (Ἐπιφάνιος ὁ πατρίκιος) replied that if the charges against Maximos 10 were false, he was right to mock the assembly: Relatio Motionis II, 113AB. Later, when Maximos 10 anathematised Origen after Menas 7 accused him of accepting Origenist views, the patrikios Epiphanios 50 remarked that he had cleared himslf of the charge: Relatio Motionis V, 120. On 9 September of the fifteenth indiction (i.e. 9 September 656), the patrikioi Troilos 3 and Epiphanios 50, together with the bishop of Caesarea, Theodosios 20, visited Maximos 10 at the monastery of St Theodoros at Rhegion; when Maximos still refused to obey the emperor and accept the Typos, the patrikioi had him flogged until stopped by Theodosios: Acta primi exilii 162A-164C. The following day Troilos 3 and Epiphanios 50 undertook to submit Maximos 10 and his disciple Anastasios 1 to further questioning in their exile at Mesembria and Perberis: Acta Primi Exilii 168AB.

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