Gregorios 42 was a priest; in 787 he represented the see of Polybotos (in Phrygia Salutaris) at the Second Council of Nikaia (the Seventh Ecumenical Council); he is attested at the fourth and seventh sessions, on 1 October and 13 October 787, and possibly attended the last five sessions, from 1 October to 23 November 787: Mansi XIII 149-486. In the list of those present at the seventh session he is styled Γρηγορίου πρεσβυτέρου καὶ ἐκ προσώπου Πολυβώτου: Mansi XIII 372. Elsewhere he is styled Γρηγόριος πρεσβύτερος καὶ ἐκ προσώπου τοῦ θρόνου πόλεως Πολυβάτου (sic), Mansi XIII 149 (the Latin version, at XIII 150, gives his name as Georgius); and Γρηγόριος ἀνάξιος πρεσβύτερος καὶ τοποτηρητὴς πολυβύτου (sic): Mansi XIII 396 (the Latin version, at XIII 395, has: "indignus presbyter et loci servator throni civitatis Polyboti"). At the fourth session he subscribed the statements read out from the Fathers in support of the veneration of icons: Mansi XIII 149. At the seventh session he subscribed the statement of the faith adopted by the Council: Mansi XIII 396.

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